Chemerin is not associated with subclinical atherosclerosis markers in prediabetes and diabetesKadriye Aydın1, Uğur Canpolat2, Şafak Akın1, Muhammet Dural2, Jale Karakaya3, Kudret Aytemir2, Necla Özer2, Alper Gürlek1
1Departments Of Endocrinology And Metabolism, Hacettepe University, Ankara- Turkey
2Cardiology, Hacettepe University, Ankara- Turkey
3Biostatistics, Faculty Of Medicine, Hacettepe University, Ankara- Turkey
Objective: Chemerin is a novel adipokine that is correlated with adipocyte differentiation, glucose metabolism, and inflammation. We aimed to investigate the relation between serum chemerin level and subclinical atherosclerosis markers as exemplified by brachial artery pulse wave velocity (baPWV), carotid intimamedia thickness (CIMT), epicardial fat thickness (EFT), and carotid plaque presence in diabetes and prediabetes.Keywords: chemerin, diabetes, pulse wave velocity, atherosclerosis, carotid plaque, epicardial fat
Methods: Age-, body mass index (BMI)-, and gender-matched patients with type 2 DM (n=30), prediabetes (n=25), and normal glucose tolerance (n=25) were included in this cross-sectional study. Serum chemerin level, lipid parameters, glucose metabolism marker, baPWV, CIMT, EFT, and anthropometric were recorded. The independent risk factors for atherosclerosis markers were determined by linear and/or multiple logistic regression analysis.
Results: baPWV and carotid plaque presence were higher in the diabetes group than in prediabetes and control groups (p=0.039 and p=0.035 respectively), whereas serum chemerin levels were similar among groups (p=0.338). Chemerin levels were not correlated with PWV, CIMT, and epicardial fat thickness overall or in the subgroups. Overall and in the diabetes group, chemerin levels were positively correlated with the key components of metabolic syndrome as BMI, total body fat percentage, waist circumference, triglyceride, and systolic and diastolic blood pressure (BP). After adjusting for age, gender, and BMI, only the association between chemerin and systolic BP remained significant. Chemerin was not found as an independent risk factor for predicting atherosclerosis in diabetes and prediabetes.
Conclusion: Chemerin is not a predictive marker for atherosclerosis in diabetes and prediabetes, but correlates well with key aspects of the metabolic syndrome particularly in diabetes. (Anatol J Cardiol 2016; 16: 749-55)
Kadriye Aydın, Uğur Canpolat, Şafak Akın, Muhammet Dural, Jale Karakaya, Kudret Aytemir, Necla Özer, Alper Gürlek. Chemerin is not associated with subclinical atherosclerosis markers in prediabetes and diabetes. Anatol J Cardiol. 2016; 16(10): 749-755
Sorumlu Yazar: Alper Gürlek, Türkiye