Assessment of left atrial appendage function during sinus rhythm in patients with obstructive sleep apneaMustafa Gökhan Vural1, Süha Çetin2, Hüseyin Gündüz3, Özge Özcan Abacıoğlu3, Ramazan Akdemir4, Hikmet Fırat4, Ekrem Yeter3
1Department Of Cardiology, Faculty Of Cardiology, Sakarya University; Sakarya-turkey
2Clinic Of Cardiology Koru Private Hospital; Ankara-turkey
3Clinics Of Cardiology, Ministry Of Health Dışkapı Yıldırım Beyazıt Research And Educational; Ankara-turkey
4Pulmonology, Ministry Of Health Dışkapı Yıldırım Beyazıt Research And Educational; Ankara-turkey
Objective: Obstructive sleep apnea (OSA) is associated with thromboembolic events. Compromised left atrial appendage (LAA) function due to left ventricular (LV) performance abnormality, often present in patients with OSA, may play an important role. The purpose of this study is to evaluate LV and LAA mechanical functions during sinus rhythm (SR) in patients with OSA.Keywords: diastolic dysfunction, left atrial appendage, obstructive sleep apnea, sinus rhythm, tissue Doppler echocardiography
Methods: LV and LAA functions were assessed in 43 OSA patients and compared with that of 20 control patients in SR. Tissue Doppler velocities of the LAA apex and emptying velocities (EV) of LAA were obtained on parasternal short-axis view.
Results: The baseline clinical characteristics were similar except for AHI (apnea-hypopnea index), minimal SaO2, mean SaO2, hypertension, and body-surface area. Most of the LV echocardiographic parameters significantly deteriorated in OSA patients in comparison with those in the control group. LAA EV, LAA systolic relaxation velocity (SM), LAA early-diastolic velocity (EM), LAA contraction velocity (AM), left atrial (LA) minimum volume index, LA ejection fraction, LA conduit volume index, and LA reservoir volume index were lower in OSA patients compared with those in the control group (p<0.05). LAA AM was negatively correlated with AHI and the ratio of peak early diastolic flow velocity (E) to early-diastolic (E′) and positively correlated with LA conduit volume (p<0.05). Multiple predictors for LAA AM were AHI, presence of diastolic dysfunction, and E/E′ values (p<0.05).
Conclusion: LAA mechanical function is significantly depressed in patients with OSA and SR. LAA dysfunction may predispose these patients to thromboembolic events. The evaluation of LAA mechanical function by tissue Doppler study using transthoracic echocardiography (TTE) may become an alternative for routine work-up in OSA patients.
Mustafa Gökhan Vural, Süha Çetin, Hüseyin Gündüz, Özge Özcan Abacıoğlu, Ramazan Akdemir, Hikmet Fırat, Ekrem Yeter. Assessment of left atrial appendage function during sinus rhythm in patients with obstructive sleep apnea. Anatol J Cardiol. 2016; 16(1): 34-41
Sorumlu Yazar: Süha Çetin, Türkiye