Telefon ve e-posta Desteği
Sıkça Sorulan Sorular
Yazarlar İçin Teknik Bilgiler
İletişim Bilgileri
Ana Sayfaya Dönüş
 

Kongre Takvimi
Buradaki bilgiler JournalAgent™ online dergicilik sisteminden alınmaktadır.

The Anatolian Journal of Cardiology

[Anatol J Cardiol]
Anatol J Cardiol. 2018; 19(2): 86-93 | DOI: 10.14744/AnatolJCardiol.2017.8069  

Lack of association of tumor necrosis factor superfamily member 4 (TNFSF4) gene polymorphisms (rs3850641 and rs17568) with coronary heart disease and stroke: A systematic review and meta-analysis

Jin- Sen Lu1, Hong Wang1, Fei- Fei Yuan1, Le- Le Wu1, Bin Wang2, Dong- Qing Ye2
1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, P. R. China
2The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, Anhui, P. R. China

Objective: To evaluate the association between the tumor necrosis factor superfamily member 4 (TNFSF4) gene polymorphisms and common cardiovascular and cerebrovascular diseases.
Method: A literature-based search was operated through database including PubMed, EMBASE, Cochrane Library, CNKI and WanFang data. Crude odds ratios (ORs) and 95% confidence intervals (CI) were calculated to estimate the strength of the association between TNFSF4 polymorphisms (rs3850641 and rs17568) and the risk of coronary heart disease and stroke.
Results: 11 eligible studies were included in this meta-analysis. It was showed that G allele was not associated with CHD and stroke, compared with A allele (rs3850641: OR 1.02, 95%CI.: 0.89, 1.17; rs17568: OR 1.09, 95%CI.: 0.89, 1.33). Genotypic analysis demonstrated that there was no significantly association between the risk of CHD and stroke and rs3850641 (homozygous comparison (GG vs. AA): OR 1.05, 95%CI.: 0.74, 1.50; heterozygous comparison (GA vs. AA): OR 1.00, 95%CI.: 0.88, 1.13; recessive model (GG vs. GA + AA): OR 1.04, 95%CI.: 0.76, 1.43; dominant model (GG + GA vs. AA): OR 1.01, 95%CI.: 0.88, 1.17). Similarly, no susceptibility between CHD and stroke and rs17568 polymorphism was uncovered (GG vs. AA: OR 1.04, 95%CI.: 0.74, 1.46; GA vs. AA: OR 1.07, 95%CI.: 0.62, 1.83; GG + GA vs. AA: OR 1.13, 95%CI.: 0.82, 1.56; GG vs. GA + AA: OR 1.01, 95%CI.: 0.74-1.39).
Conclusions: The present study demonstrated that there is no significant relationship between TNFSF4 gene polymorphism and cerebrovascular and cardiovascular diseases.

Keywords: tumor necrosis factor superfamily member 4, coronary heart disease, stroke, polymorphism, meta-analysis


Jin- Sen Lu, Hong Wang, Fei- Fei Yuan, Le- Le Wu, Bin Wang, Dong- Qing Ye. Lack of association of tumor necrosis factor superfamily member 4 (TNFSF4) gene polymorphisms (rs3850641 and rs17568) with coronary heart disease and stroke: A systematic review and meta-analysis. Anatol J Cardiol. 2018; 19(2): 86-93

Sorumlu Yazar: Bin Wang, China


ARAÇLAR
Tam Metin PDF
Yazdır
Alıntıyı İndir
RIS
EndNote
BibTex
Medlars
Procite
Reference Manager
E-Postala
Paylaş
Yazara e-posta gönder

Benzer makaleler
PubMed
Google Scholar




 

 
 

Online Kongre Hizmetleri
Kongre Web Sitesi
Bildiri Özeti Toplama ve Değerlendirme
Online Kayıt ve Konaklama
Elektronik Poster (e-poster)
Video Podcast, WebCast
Bilimsel Program Düzenleyici
Bildiri Özeti ve Tam Metin CD'leri
 

Online Kurumsal Hizmetler
Dernekler İçin Web Siteleri
Hakemli Dergiler İçin Online Makale Toplama
   ve Değerlendirme

Uluslararası Dizin Danışmanlığı
PubMed®, LinkOut® Hizmetleri
Online Çalışma Grupları
 

Referans
Çalıştığımız Online Hakemli Dergiler
Destek Verdiğimiz Kongreler
Yazarlar İçin Teknik Bilgiler

İletişim
Bize Ulaşın
LookUs

 
 
1999 - 2019 © LookUs Scientific

Bu sitede sözü edilen uygulamalara ait teknoloji, uygulama metodu, ekran görünüşleri; ticari marka, ticari görünüm, kanun dışı rekabet ve başka kanunlarca; yerel ve uluslararası copyright düzenlemeleri ile korunmuştur. Site üzerindeki herhangi bir metin ve imaj LookUs Bilişim Hizmetleri Ltd.'nin açık ve net izni olmadan kopyalanamaz veya dağıtılamaz.
Metinler ve şekiller içinde geçen gerçek şirket ve ürün adları, ilgili firmaların ticari markaları olabilir.