Echocardiographic assessment of right ventricular functions in healthy subjects who migrated from the sea level to a moderate altitudeArif Arısoy1, Selim Topçu2, Selami Demirelli3, Fatih Altunkaş1, Metin Karayakalı1, Ataç Çelik1, İbrahim Halil Tanboğa2, Enbiya Aksakal2, Serdar Sevimli2, Hanefi Yekta Gürlertop4
1Department Of Cardiology, Faculty Of Medicine, Gaziosmanpaşa University, Tokat- Turkey
2Department Of Cardiology, Faculty Of Medicine, Atatürk University, Erzurum- Turkey
3Department Of Cardiology, Erzurum Regional Training And Research Hospital, Erzurum- Turkey
4Department Of Cardiology, Faculty Of Medicine, Trakya University, Edirne- Turkey
Objective: The aim of this study was to evaluate right ventricle (RV) functions using echocardiography in healthy subjects who migrated from the sea level to moderate altitude (1890 m).Keywords: tissue Doppler, right ventricle, high altitude
Methods: The prospective observational in this study population consisted of 33 healthy subjects (23 men; mean age 20.4±3.2 years) who migrated from the sea level to a moderate altitude (Erzurum city centre, 1890 m above sea level) for long-term stay. Subjects underwent echocardiographic evaluation within the first 48 h of exposure to the moderate altitude and at the sixth month of arrival. Conventional echocardiographic parameters such as RV sizes and areas, systolic, and diastolic functional indices [fractional area change (FAC), tricuspid flow velocities, myocardial performance index (MPI), and tricuspid annular plane systolic excursion (TAPSE)] were obtained. Systolic (S) and diastolic (E, A) velocities were acquired from the apical four-chamber view using tissue Doppler imaging. KolmogorovSmirnov test, students t-test, Wilcoxon test, and chi-square test were used in this study.
Results: There were no significant changes in RV size, FAC, MPI, TAPSE, inferior inspiratory vena cava collapse, tricuspid E velocity, and tricuspid annulus E velocity. Compared with the baseline, there was a significant increase in mean pulmonary artery pressure (p=0.001); RV end systolic area (p=0.014); right atrial end diastolic area (p=0.021); tricuspid A velocity (p=0.013); tricuspid annulus S and A velocity (p=0.031 and p=0.006, respectively); and RV free wall S, E, and A velocity (p=0.007, p<0.001, and p=0.007 respectively) at the sixth month. Also, there was a significant decrease in tricuspid E/A ratio (1.61±0.3 vs. 1.45±0.2, p=0.038) and tricuspid annulus E/A ratio (1.52±0.5 vs. 1.23±0.4, p=0.002) at the sixth month.
Conclusion: Our study revealed that right ventricular diastolic function was altered while the systolic function was preserved in healthy subjects who migrated from the sea level to a moderate altitude. (Anatol J Cardiol 2016; 16: 779-83)
Arif Arısoy, Selim Topçu, Selami Demirelli, Fatih Altunkaş, Metin Karayakalı, Ataç Çelik, İbrahim Halil Tanboğa, Enbiya Aksakal, Serdar Sevimli, Hanefi Yekta Gürlertop. Echocardiographic assessment of right ventricular functions in healthy subjects who migrated from the sea level to a moderate altitude. Anatol J Cardiol. 2016; 16(10): 779-783
Sorumlu Yazar: Arif Arısoy, Türkiye