Telefon ve e-posta Desteği
Sıkça Sorulan Sorular
Yazarlar İçin Teknik Bilgiler
İletişim Bilgileri
Ana Sayfaya Dönüş
 

Kongre Takvimi
Buradaki bilgiler JournalAgent™ online dergicilik sisteminden alınmaktadır.

The Anatolian Journal of Cardiology

[Anatol J Cardiol]
Anatol J Cardiol. 2013; 13(4): 306-314 | DOI: 10.5152/akd.2013.106  

Increased apolipoprotein A-I levels mediate the development of prehypertension among Turks

Altan Onat1, Günay Can2, Ender Örnek3, Gökhan Çiçek4, Sani N. Murat5, Hüsniye Yüksel6
1Department of Cardiology, Turkish Society of Cardiology, Cerrahpaşa Faculty of Medicine, İstanbul-Turkey
2Department of Public Health, Cerrahpaşa Faculty of Medicine, İstanbul University, İstanbul- Turkey
3Clinic of Cardiology, Etlik İhtisas Education Hospital, Ankara-Turkey
4Clinic of Cardiology, Siyami Ersek Center for Cardiovascular Surgery, İstanbul-Turkey
5Clinic of Cardiology, Etlik Ihtisas Educational Hospital, Ankara-Turkey
6Department of Cardiology, Turkish Society of Cardiology Cerrahpaşa Medical Faculty, İstanbul-Turkey

Objective: We aimed to assess whether apolipoprotein (apo) A-I levels that generated type-2 diabetes and coronary disease among Turks contribute to prehypertension and hypertension. Methods: A population-based sample of 2207 adults (mean age 53±11 years) was studied prospectively over a 6.5 years’ follow-up. Individuals with hypertension and/or prehypertension were excluded at baseline. Results: At baseline, levels of apoA-I increased in each sex, from the normotensive to prehypertensive and hypertensive group (by mean 7.6 mg/dL, p<0.001) concomitantly with age, waist circumference, fasting triglycerides, apoB, C-reactive protein (CRP) and homeostasis model assessment. In logistic regression models, adjusted for confounders comprising waist circumference or triglycerides, prehypertension was predicted independently by apoA-I at RRs of 1.23 (95%CI 0.97; 1.52)] or 1.32 (95%CI 1.04; 1.74), respectively. Despite showing a positive association, apoA-I did not independently predict in similar models the development of hypertension; the determinants were rather waist circumference, or fasting triglycerides or CRP [RR 1.16 (95%CI 1.05; 1.28)] and, in women, diabetes. In a linear regression analysis for circulating apoA-I including 10 variables, apoB and in men systolic blood pressure were positively associated. Conclusion: In contributing to prehypertension, the pro-inflammatory apoA-I, mediated by apoB, is independent of triglyceridemia. Other inflammatory processes conjointly are likely mechanistically involved in the development of hypertension in a population with prevalent metabolic syndrome.

Keywords: Apolipoproteins, C-reactive protein, diabetes type-2, obesity, prehypertension, systemic inflammation, regression analysis


Altan Onat, Günay Can, Ender Örnek, Gökhan Çiçek, Sani N. Murat, Hüsniye Yüksel. Increased apolipoprotein A-I levels mediate the development of prehypertension among Turks. Anatol J Cardiol. 2013; 13(4): 306-314


ARAÇLAR
Tam Metin PDF
Yazdır
Alıntıyı İndir
RIS
EndNote
BibTex
Medlars
Procite
Reference Manager
E-Postala
Paylaş


Benzer makaleler
PubMed
Google Scholar




 

 
 

Online Kongre Hizmetleri
Kongre Web Sitesi
Bildiri Özeti Toplama ve Değerlendirme
Online Kayıt ve Konaklama
Elektronik Poster (e-poster)
Video Podcast, WebCast
Bilimsel Program Düzenleyici
Bildiri Özeti ve Tam Metin CD'leri
 

Online Kurumsal Hizmetler
Dernekler İçin Web Siteleri
Hakemli Dergiler İçin Online Makale Toplama
   ve Değerlendirme

Uluslararası Dizin Danışmanlığı
PubMed®, LinkOut® Hizmetleri
Online Çalışma Grupları
 

Referans
Çalıştığımız Online Hakemli Dergiler
Destek Verdiğimiz Kongreler
Yazarlar İçin Teknik Bilgiler

İletişim
Bize Ulaşın
LookUs

 
 
1999 - 2019 © LookUs Scientific

Bu sitede sözü edilen uygulamalara ait teknoloji, uygulama metodu, ekran görünüşleri; ticari marka, ticari görünüm, kanun dışı rekabet ve başka kanunlarca; yerel ve uluslararası copyright düzenlemeleri ile korunmuştur. Site üzerindeki herhangi bir metin ve imaj LookUs Bilişim Hizmetleri Ltd.'nin açık ve net izni olmadan kopyalanamaz veya dağıtılamaz.
Metinler ve şekiller içinde geçen gerçek şirket ve ürün adları, ilgili firmaların ticari markaları olabilir.