The Anatolian Journal of Cardiology

Aspirin Direnci [Anatol J Cardiol]
Anatol J Cardiol. 2004; 4(1): 59-62

Aspirin Direnci

Mehmet Birhan Yılmaz1, Yücel Balbay2, Şule Korkmaz3
1Cumhuriyet Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Sivas
2Ankara Türkiye Yüksek İhtisas Hastanesi, Kardiyoloji Bölümü, Ankara, Türkiye
3Department of Cardiology, Yüksek İhtisas Heart-Education and Research Hospital, Ankara, Turkey

Anahtar Kelimeler: Aspirin direnci, trombositler, siklooksijenaz


Aspirin Resistance

Mehmet Birhan Yılmaz1, Yücel Balbay2, Şule Korkmaz3
1Cumhuriyet Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Sivas
2Ankara Türkiye Yüksek İhtisas Hastanesi, Kardiyoloji Bölümü, Ankara, Türkiye
3Department of Cardiology, Yüksek İhtisas Heart-Education and Research Hospital, Ankara, Turkey

Aspirin is an effective antithrombotic agent for many patients. However, patients taking aspirin might exhibit variable responses to in vitro tests for platelet aggregation and might experience breakthrough thromboembolic events. Although this phenomenon has been called aspirin resistance, the lack of an uniform definition or agreement on diagnostic criteria precludes definitive recommendations at this time. Aspirin resistance has been defined in patients with cardiovascular, cerebrovascular, and peripheral vascular disease. In this article, mechanisms related with aspirin resistance and clinical background in which resistance is defined, are reviewed.

Keywords: Aspirin resistance, thrombocytes, cyclooxygenase


Mehmet Birhan Yılmaz, Yücel Balbay, Şule Korkmaz. Aspirin Resistance. Anatol J Cardiol. 2004; 4(1): 59-62


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