Effects of selenium supplementation on sFlt-1, GPx level and the PAI1/PAI2 ratio in the pregnant womenMina Mosavi, Majid Ghayour, Shabnam Mohammadi
OBJECTIVE: Preeclampsia is a hypertensive disorder of pregnancy, which is associated with increased maternal and prenatal morbidity and mortality. Oxidative stress associated with preeclampsia may be consequence of reduced antioxidant defense pathways that might involve inadequate glutathione peroxidase (GPx), perhaps linked to reduced selenium availability. The soluble fms-like tyrosine kinase-1 (sFlt-1) contribute to endothelial dysfunction maybe partially responsible for the clinical manifestation of preeclampsia. Furthermore, elevated plasminogen activator inhibitor-1 (PAI-1) and decreased plasminogen activator inhibitor-2 (PAI-2) are found in preeclamptic women. Hence, the PAI1/ PAI2 ratio maybe a predictor of preeclampsia. The objective of this study was to evaluate the effects of selenium supplementation on sFlt-1, GPx activity and the PAI1/PAI2 ratio in pregnant women.Keywords: Fms-like Tyrosine Kinase 1, glutathione peroxidase, PAI1/PAI2 ratio, preeclampsia, selenium
METHODS: A total of 166 high- risk pregnant women in the first trimesters of pregnancy were selected and randomly allocated to either selenium or placebo. The selenium group received 100μg/day selenium as a selenium-yeast tablet for six months. The placebo group received a placebo yeast tablet for the same period. At the beginning of the trail and at the term, blood samples were collected and the levels of sFlt-1, PAI-1, PAI2 and GPx were measured in blood serum and plasma.
RESULTS: Serum selenium concentration was increased in the selenium group from the first to the third three mister, but was unchanged in placebo group.The results showed that sFlt-1 had significantly increased in both groups by the end of the gestation, and Selenium supplementation had no significant effect on Selenium group (P>0.05). GPx activity increased in the selenium treatment group after supplementation compared to the control group (P<0.05). The PAI1/PAI2 ratio was not significantly different between the two groups (P>0.05).
CONCLUSION: Selenium intake in the second and third trimester of pregnancy increased GPx activity but did not influence sFlt-1 level nor the ratio of PAI1/PAI2 in the serum.
Mina Mosavi, Majid Ghayour, Shabnam Mohammadi. Effects of selenium supplementation on sFlt-1, GPx level and the PAI1/PAI2 ratio in the pregnant women. . 2012; 10(3): 2500-2506
Sorumlu Yazar: Majid Ghayour, Iran